Pharmaceutical composition containing zinc complex of...

Details Pharmaceutical composition containing zinc complex of... Pharmaceutical composition containing zinc complex of...

A - Human Necessities

61

K

167/122

A61K 31/555 (2006.01) C07D 215/30 (2006.01)

Patent

CA 1306685

- 24 - A PHARMACEUTICAL COMPOSITION COMPRISING AN ORGANIC ZINC COMPLEX AND A PROCESS FOR PREPARING THE ACTIVE SUBSTANCE A b s t r a c t The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxy- quinoline of formula (I) Image (I) - 25 - and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails. The complex of formula (I) is prepared by react- ing a solution of an alkali metal salt of 5-chloro-7- -iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.

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