Antioestrogenic phenol derivatives

Details Antioestrogenic phenol derivatives Antioestrogenic phenol derivatives

C - Chemistry, Metallurgy

07

C

167/179, 260/643

C07C 317/18 (2006.01) A61K 31/10 (2006.01) C07C 45/46 (2006.01) C07C 45/51 (2006.01) C07C 45/68 (2006.01) C07C 49/755 (2006.01) C07C 49/757 (2006.01) C07C 65/40 (2006.01) C07C 323/16 (2006.01) C07F 7/18 (2006.01) C07F 9/50 (2006.01)

Patent

CA 1291991

A B S T R A C T PHENOL DERIVATIVES A phenol derivative of the formula Nu-A-x-R1 wherein NU is a defined phenolic nucleus including a phenyl-hydroxynaphthyl; hydroxyphenyl-naphthyl; phenyl-hydroxyindanyl, phenyl-hydroxybenzothienyl or mono-hydroxyphenyl-ethylene or vinylene nucleus; wherein A is alkylene, alkenylene or alkynylene which may be interrupted by phenylene or other linkages, wherein R1 is hydrogen, or alkyl, alkenyl, alkynyl, cycloalkyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxyalkyl, aryl or arylalkyl, or R1 is joined to R2, and wherein X is -CONR2-, -CSNR2-, -NR12CO-, -NR12CS- R12CONR2- Image , -SO2NR2- or -CO-, or, when R1 is not hydrogen, is -NR12COO-, -(PO)R2-, -S-, -SO- or -SO2-, wherein R2 is hydrogen or alkyl, or R1 and R2 together form alkylene; wherein R12 is hydrogen or alkyl, and wherein R22 is hydrogen, cyano or nitro; or a salt thereof when appropriate. The compounds possess antioestrogenic activity and may be used for the treatment of hormone-dependent breast tumours or of anovulatory infertility.

480145

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