Process for enzymatic production of peptides

Details Process for enzymatic production of peptides Process for enzymatic production of peptides

C - Chemistry, Metallurgy

12

P

195/128.7

C12P 21/02 (2006.01)

Patent

CA 1177429

Abstract A peptide having the formula A-B wherein A represents an N-terminal protected amino acid residue or an optionally N-terminal protected peptide residue and B represents an optionally C-terminal protected amino acid residue, is prepared by reacting a substrate component selected from the group consisting of optionally N-terminal protected peptides of the formula A-X wherein A is as defined above and X represents an amino acid with an amine component selected from the group consis- ting of (a) amino acids of the formula H-B-OH, (b) optionally N-substituted amino acid amides of the formula H-B-NHR3 wherein B is an amino acid residue and R3 represents hydrogen, hydroxy, amino or alkyl, aryl or aralkyl, and (c) amino acid esters of the formula H-B-OR4 or H-B-SR4 wherein B is an amino acid residue and R4 represents alkyl, aryl and aralkyl, in the presence of a carboxypeptidase enzyme in an aqueous solution or dispersion having a pH from 5 to 10.5, preferably at a temperature of from 20 to 50°C, to form a peptide, and subsequently cleaving a group H, -NR3R3', -OR4, -SR4 or-SeR4 or an N-terminal protective group, if desired.

422838

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