A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/180, 167/310
A61K 31/56 (2006.01) A61K 31/65 (2006.01) A61K 31/71 (1985.01)
Patent
CA 1226523
ABSTRACT: ANTIANDROGEN AND ANTIBIOTIC TREATMENT OF ACNE PHARMACEUTICAL] PREPARATIONS THEREFOR A pharmaceutical formulation for systemic use in treating acne vulgaris comprising at least one anti-androgen and at least one antibiotic, wherein when the formulation is in unit dosage form the anti-androgen (with progesterone-like properties e.g. cyproterone acetate) is present in an amount of at least 10mg daily given over 10 days or 100mg or more in total given during a complete cycle over 21 - 28 days e.g. about 3.5mg to 5.0mg daily or as a single or divided dose. A calendar pack containing pharmaceutical formulation doses for use in treating female acne vulgaris comprising spaced location corresponding to the days of a menstrual cycle, dosage forms in a first series of said locations providing at the or each location of the series a daily dose of an anti-androgen and a dose of an antibiotic in pharmaceutically administerable form, and dosage forms at a further series of locations following the first series providing a daily dose of antibiotic in pharmaceutically-administerable form without anti-androgen, wherein the dose of anti-androgen is such that at least 100mg is provided per cycle. A topical pharmaceutical formulation for use comprising a combination of at least one anti-androgen and at least one antibiotic, together with at least one of the conventional pharmaceutically-acceptable carriers, diluents and excipents.
444482
Fetherstonhaugh & Co.
Mortimer Christopher H.
LandOfFree
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