Process for the preparation of 2-/e/phenyl-...

Details Process for the preparation of 2-/e/phenyl-... Process for the preparation of 2-/e/phenyl-...

A - Human Necessities

61

K

260/591.7

A61K 31/15 (2006.01)

Patent

CA 1210027

ABSTRACT The invention relates to a process for the preparation of 2-/E/-phenylmethylenecycloheptan-1-one-/E/-oxime of the formula /I/ Image /I/ free of other isomers. According to the invention the compound of the formula /I/ is prepared by reacting 2-/E/-phenylmethylene- cycloheptzn-1-one of the formula /II/ Image with hydroxylamine obtained "in situ" from a hydroxylamine salt in the presence of a base. The reaction is carried out in water and/or in a lower, with water unrestrictedly miscible aliphatic alcohol, and subsequently the alcohol content of the reaction medium is adjusted to 40-60 %. The compound of the formula /I/ is isolated from the reaction mixture by known methods. -2- The 2-/E/-phenylmethylenecycloheptan-1-one-/E/-oxime of the formula /I/ serves as intermediate for the synthesis of compounds possessing valuable pharmaceutical properties.

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