Process for producing a hepatitis b infection preventing...

Details Process for producing a hepatitis b infection preventing... Process for producing a hepatitis b infection preventing...

A - Human Necessities

61

K

167/130

A61K 39/29 (2006.01) C07K 14/02 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1217138

ABSTRACT A process for producing a hepatitis B infection preventing vaccine containing hepatitis B surface antigen as a main component thereof which comprises removing human plasma components possibly causing adverse effects and components capable of causing hepatitis B infection by incorporating steps of fractionation using ammonium sulfate, adsorption on a colloidal silicate and fractiona- tion using polyethylene glycol into the purification stage after heat treatment and further carrying out a treatment for infectivity inactivation without causing any antigenicity impairment.

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