C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
167/234, 260/386
C07F 9/24 (2006.01) C07F 9/6558 (2006.01)
Patent
CA 1238327
- 1 - 4-14507/+ Substituted thiazolidinyl esters of mineral acid amides Abstract The invention relates to novel compounds of the general formula Image I in which one of the symbols R1 and R2 represents an alkyl radical having 3 or 4 carbon atoms that is un- saturated in the 2,3-position and the other represents such a radical or lower alkyl, each of R3 and R4, independently of the other, represents hydrogen or methyl, each of R5 and R6, independently of the other, represents hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R5 and R6 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, and X represents OR7 or NR8R9 in which R7 represents hydrogen or lower alkyl and each of R8 and R9, independently of the other, represents - 2 - hydrogen, lower alkyl, halogenated lower alkyl, or lower alkenyl or R8 and R9 together represent lower alkylene that is optionally interrupted by oxygen, sulphur or by optionally substituted nitrogen, or R6 together with R7 or R8 represents a lower alkylene group, and to salts of compounds of the general formula I in which R7 represents hydrogen. These compounds and their salts exhibit anti-tumour activities.
459023
Fetherstonhaugh & Co.
Novartis Ag
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