Process for the manufacture of 1,2-disubstituted...

C - Chemistry – Metallurgy – 07 – D

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C07D 217/04 (2006.01) C07D 217/20 (2006.01)

Patent

CA 1310012

Abstract A process for the manufacture of the isoquinolines of the formula Image (I) wherein R is methyl or benzyl and R' is phenyl, p-hydroxyphenyl or p-methoxyphenyl, by reacting a solution of an enamine of the formula Image II wherein R and R' have the above significance, in a hydrocarbon with an anhydrous solution of p-toluene- sulphonic acid in toluene or xylene at an elevated temper- ature.

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