Synthesis of srs-active compounds

Details Synthesis of srs-active compounds Synthesis of srs-active compounds

C - Chemistry, Metallurgy

07

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260/369.5

C07D 301/00 (2006.01) C07C 29/10 (2006.01) C07C 29/36 (2006.01) C07C 29/40 (2006.01) C07C 45/29 (2006.01) C07C 47/20 (2006.01) C07D 303/00 (2006.01) C07D 303/42 (2006.01) C07D 333/46 (2006.01)

Patent

CA 1175853

HAN 4050/12 Abstract Oxiranebutanoic acid esters of the formula Image I wherein R represents the group CH3-CH2-CH2-CH2-CH2-, R2 represents lower alkyl, aryl or aryl lower alkyl and .DELTA. ' designates a trans configuration across the double bond. are valuable SRS-A antagonists, and thus, are useful agents for treating allergic reactions, especially in the treatment of bronco-constriction. These compounds are also useful intermediates for the preparation of SRS-A active compounds which in turn are useful standard compounds in the screening of SRS-A antagonists. They can be prepared by reacting a compound of formula Image II wherein Y represents halogen and R5 and R6 individually represent methyl or ethyl or taken together with their attached sulfur atom form a saturated 4 to 6 member heterocyclic ring with said attached sulfur atom as the only hetero atom; and .DELTA.' has the meaning indicated above, with a corresponding 4-formyl butyric acid ester.

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