Quinone derivatives, their production and use

Details Quinone derivatives, their production and use Quinone derivatives, their production and use

C - Chemistry, Metallurgy

07

D

167/208, 260/295

C07D 213/24 (2006.01) C07D 213/50 (2006.01) C07D 213/55 (2006.01) C07D 233/22 (2006.01) C07D 409/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1285562

Abstract of the disclosure 24205-707 Quinone derivatives represented by the general formula Image (I) (wherein, R1 and R2, the same or different, are hydrogen atom, methyl or methoxy group, or R1 and R2 bind together to form -CH=CH-CH=CH-; R3 is hydrogen atom or methyl group; R4 is nitrogen-containing heterocyclic group which may be substituted; R5 is hydrogen atom, methyl group, hydroxymethyl group which may be substituted, or carboxyl group which may be esterified or amidated; Z is Image , -CH=CH-, Image , or Image (wherein, R' is hydrogen atom or methyl group); n is an integer from 0 through 12, m is an integer from 0 through 3, and k is an integer from 0 through 7, providing that,when m is 2 or 3, Z and k are able to vary appropri- ately in the repeating unit shown in [ ] ), and the hydro- quinone derivatives thereof, are novel compounds, possess improvement effects of metabolism of polyunsaturated fatty acids, particularly two or more of inhibition of production of fatty acid peroxides, inhibition of production of metabo- lites in 5-lipoxygenase pathway, inhibition of thromboxane A2 synthetase, thromboxane A2 receptor antagonism and scavenging action of active oxygen species, and of use as drugs, such as antithrombotics, anti-vascular constriction agents, anti-asthma agent, antiallergic agents, therpeutics for psoriasis, agents for improvement in heart, brain and cardiovascular systems, therapeutics for nephritis, active oxygen-eliminating agents, anticancer agents, agents for improvement of control of arachidonate cascade products, etc.

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