C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/107, 167/185
C12P 17/08 (2006.01) A01N 43/02 (2006.01) A01N 43/90 (2006.01) A01N 63/00 (2006.01) A23K 1/17 (2006.01) A61K 31/365 (2006.01) C07H 17/08 (2006.01) C07H 19/01 (2006.01) C12P 19/60 (2006.01)
Patent
CA 1339309
Antiparasitic compounds of formula (I): (see fig.I) The broken line at the 22-23 position representing an optional double bond and either R1 is H or OH and the double bond is absent or the double bond is present and R1 is absent; R2 is optionally substituted phenyl, or a group of formula (II): (see fig. II) wherein X is O, S or -CH2-, a, b, c and d are 0-2 a+b+c+d ~ 5; R3 is H or Me; R4 is H, OH or 4'-(alpha-L-oleandrosyl) -alpha-L-oleandrosyloxy. The compounds are prepared by fermentation of Streptomyces avermitilis in the presence of an N-alkanoyl cysteamine thioester containing R2. .
604521
Dutton Christopher James
Gibson Stephen Paul
Walshe Nigel Derek Arthur
Pfizer Inc.
Smart & Biggar
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