Sulphonamides

Details Sulphonamides Sulphonamides

C - Chemistry, Metallurgy

07

D

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C07D 455/00 (2006.01) C07D 471/14 (2006.01) C07D 491/14 (2006.01) C07D 491/147 (2006.01) C07D 495/14 (2006.01)

Patent

CA 1308720

H-368/376 ABSTRACT SULPHONAMIDES The invention concerns sulphonamides of general formula Image (I) and their pharmaceutically acceptable acid addition salts. In formula (I), R represents hydrogen or lower alkyl, R1 and R2 which may be the same or different each represents hydrogen, lower alkyl, lower alkoxy or halogen, R3 and R4 which may be the same or different each represents lower alkyl, halo(lower)alkyl or aryl, A represents a lower alkylene group having 1 to 3 carbon atoms in the chain between the two N atoms and X represents O, S or NR5 (where R5 is hydrogen or lower alkyl). The compounds possess .alpha.2-adrenoceptor antagonistic activity in warm blooded animals.

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