Process for the preparation of 2,3-difluoropyridine compounds

Details Process for the preparation of 2,3-difluoropyridine compounds Process for the preparation of 2,3-difluoropyridine compounds

C - Chemistry, Metallurgy

07

D

260/295.2

C07D 213/61 (2006.01) C07D 213/643 (2006.01) C07D 213/73 (2006.01)

Patent

CA 1226865

Process for the preparation of 2,3-difluoropyridine compounds Abstract of the Disclosure In accordance with a novel process, 2,3-difluoropyridines of formula I Image (I) wherein X is halogen or trifuloromethyl, are prepared by diazotis- ing a 3-amino-2-halopyridine of formula II Image (II) wherein X is as defined for formula I and Y is bromine, chlorine or fluorine, in the presence of hydrogen fluoride, to give a 3- fluoro-2-halopyridine of formula III Image (III) wherein X and Y are as defined for formula II, and treating resul- tant 3-fluoro-2-halopyridines of formula III, wherein Y is bromine or chlorine, with a fluorinating agent. The 2,3-difluoropyridines prepared by the novel process are valuable intermediates for the preparation of 2-[4-(3-fluoropyridin-2-yloxy)-phenoxy]propionic acid derivatives which are known as herbicides.

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