Bioadhesives for cell and tissue adhesion

Details Bioadhesives for cell and tissue adhesion Bioadhesives for cell and tissue adhesion

C - Chemistry, Metallurgy

12

N

195/145, 167/327

C12N 11/06 (2006.01) A61L 27/00 (2006.01) A61L 27/38 (2006.01) C12M 3/04 (2006.01) C12N 5/00 (2006.01)

Patent

CA 1328237

ABSTRACT OF THE DISCLOSURE A cell culturing system, methods for the preparation thereof, and method for affixing other biologically active moieties to a substrate are provided. Said cell culturing system comprises: a substrate; a coating thereon of a sterile formulation comprising polyphenolic protein containing from about 35 to 100% by weight pure bioadhesive polyphenolic protein having a repeating decapeptide unit: Image wherein N is a whole number ranging from about 10 to about 100, wherein each X is independently selected from the group consisting of hydroxyl and hydrogen, and wherein each R is independently selected from the group consisting of hydrogen and methyl; viable cells affixed to said coated substrate; and a nutritive medium contacting said cells, whereby said cells perform normal metabolic cell functions.

535245

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