N-substituted diphenylpiperidines

Details N-substituted diphenylpiperidines N-substituted diphenylpiperidines

C - Chemistry, Metallurgy

07

D

167/211, 260/251

C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1281326

ABSTRACT Diphenylpiperidines of the formula Image I wherein R1 is CH, C=CH or CH-CH2 R2 is alkylene or CO-(CH2)n, wherein n is 0 to 11 R3 and R4 are hydrogen. halogen or lower alkoxy Het is pyridyl, pyrimidinyl or imidazolyl and salts thereof with a pharmaceutically acceptable acid possess insulin lowering activity and are useful in the treatment of obesity.

519718

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