Pyrido[2,3-d]pyrimidine deratives

Details Pyrido[2,3-d]pyrimidine deratives Pyrido[2,3-d]pyrimidine deratives

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01)

Patent

CA 1340792

Derivatives of N-[2-(5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-6-yl)- alkyl]benzol-L-glutamic acid are antineoplastic agents. A typical embodiment is N-(2-fluoro- 4-[2-(2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido-[2,3-d]pyrimidin-6- yl)ethyl]benzoyl)-L- glutamic acid.

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