Agent for the therapy of factor viii-resistant hemophilia a,...

Details Agent for the therapy of factor viii-resistant hemophilia a,... Agent for the therapy of factor viii-resistant hemophilia a,...

A - Human Necessities

61

K

167/103.05

A61K 38/37 (2006.01)

Patent

CA 1321139

86/B 021 - Ma 574 Dr. Ha/Bi Abstract of the disclosure: An agent for the therapy of hemophilia A which is resis- tant to treatment with factor VIII is described, and is obtainable by maintaining a mixture of factor VIII, antithrombin III, a phospholipid and calcium ions in an aqueous solution at a temperature of from 1 to 45°C for at least one minute, adding factor IX, and maintaining the solution at a temperature of from 1 to 45°C until addition of a sample of this solution to an inhibitor plasma results in a partial thromboplastin time (PTT) of 15 to 30 seconds, where appropriate adding a polyol and, where appropriate, an amino acid, and, where appro- priate, drying the solution.

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