Method for technetium/rhenium labeling of proteins

Details Method for technetium/rhenium labeling of proteins Method for technetium/rhenium labeling of proteins

C - Chemistry, Metallurgy

12

N

167/101, 167/129

C12N 9/00 (2006.01) A61K 51/00 (2006.01) A61K 51/08 (2006.01) A61K 51/10 (2006.01) C07B 59/00 (2006.01) C07K 1/13 (2006.01) G01N 33/534 (2006.01)

Patent

CA 1335267

A method for radiolabeling a protein with a radioisotope of technetium or rhenium comprises the steps of contacting a solution of a protein containing a plurality of adjacent free sulfhydryl groups, or in particular cases, intact protein containing at least one disulfide group, with stannous ions, and then with radiopertechnetate or radioperrhenate, the amount of stannous ion being sufficient to substantially completely reduce the radiopertechnetate or radioperrhenate, and recovering radiolabeled protein.

615461

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