Diphenyl and phenyl pyridyl antihistamines

Details Diphenyl and phenyl pyridyl antihistamines Diphenyl and phenyl pyridyl antihistamines

C - Chemistry, Metallurgy

07

D

167/179, 260/295

C07D 401/06 (2006.01) A61K 31/44 (2006.01) A61K 31/485 (2006.01) C07D 213/55 (2006.01) C07D 213/56 (2006.01) C07D 213/61 (2006.01) C07D 213/79 (2006.01) C07D 295/14 (2006.01) C07D 295/155 (2006.01) C07D 405/04 (2006.01)

Patent

CA 1249830

Abstract Compounds of the formula (1): Image or salts, esters or amides thereof; wherein R1 is a C1-7 bivalent aliphatic hydrocarbon group or a single bond; R2 and R3 are the same or different and are each hydrogen, C1-4 alkyl or taken together with the nitrogen comprise a nitrogen-containing heterocyclic ring having four to six ring members; R4 is hydrogen, halogen, hydroxy, cyano, C1-4 acyloxy, C1-4 alkoxy or C1-4 alkyl optionally substituted by one to three halogen atoms, X is -N= or -CH=; and A and B each represents hydrogen atoms or -CA-CB= represents -C=C- are useful in the symptomatic treatment of allergic conditions. Processes for preparing the compounds, intermediates useful in their preparation, pharmaceutical compositions containing them and their use in the symptomatic treatment of allergic conditions are also described.

420912

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