A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/245, 167/251
A61K 31/335 (2006.01) A61K 31/165 (2006.01) A61K 31/19 (2006.01) A61K 31/275 (2006.01) A61K 31/36 (2006.01) C07D 317/62 (2006.01)
Patent
CA 1334826
There are provided pharmaceutical compositions containing as an active ingredient a compound of the general formula (I): Image (I) wherein R1 and R2 are each independently CN, CONH2 or COOH or one of R1 and R2 may be -CSNH2 or, when R1 is CN, R2 can also be the group Image , R3 is H, CH3 or OH, R4, R5, R6, R7 are each independently H, OH, C1-5 alkyl, C1-5 alkoxy, NH2, CHO, halogen, NO2 or COOH, or R4 and R5 together may represent a group -O-CH2-O-; provided that: (a) when R4 and R7 are each OH, R3, R5 and R6 are each H and one of R1 and R2 is CN, then the other of R1 and R2 cannot be CONH2; and (b) when R3 and R7 are each H, R5 is OH and R4 and R6 are both H or both C1-5 alkyl, then R1 is CN and R2 is CN or the group Image ; or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier. The compositions according to the invention are efficient protein-tyrosine kinase inhibitors and are suitable for the inhibition of proliferative processes in mammalian cells.
586859
Chorev Michael
Gazit Aviv
Gilon Chaim
Levitzki Alexander
Swabey Ogilvy Renault
Yissum Research Development Company Of The Hebrew University Of
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