Liposoluble platinum (ii) complex and preparation thereof

Details Liposoluble platinum (ii) complex and preparation thereof Liposoluble platinum (ii) complex and preparation thereof

C - Chemistry, Metallurgy

07

J

167/119, 260/4,

C07J 41/00 (2006.01) A61K 31/575 (2006.01) C07J 51/00 (2006.01) C07J 63/00 (2006.01)

Patent

CA 1283904

ABSTRACT OF THE INVENTION New delivatives of platinum (II) complex which are liposoluble and applicable as antibacterial agents or anticancer agents specific to the affected parts of patients and selectively transferred to the parts when they are used in combination with lipidol, the delivatives being represented by the general formula of: Image (I) (wherein R1 and R2 each stands for a ligand ammine which may have an organic substituent or may be bonded to each other through a bivalent organic group and R3 represents a bile acid residue). These delivatives being prepared by nitrifying a cis-dichloro-di-(substituted or unsubstituted)-ammine platinum (II) and then reacting the resulting aqua type product with a corresponding alkali metal salt of bile acid.

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