Methods for the treatment and prophylaxis of diaper rash and...

A - Human Necessities – 61 – L

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167/119, 167/1.5

A61L 15/00 (2006.01) A61F 13/15 (2006.01) A61L 15/18 (2006.01)

Patent

CA 1225026

METHODS FOR THE TREATMENT AND PROPHYLAXIS OF DIAPER RASH AND DIAPER DERMATITIS ABSTRACT Methods for the treatment and prevention of diaper rash and diaper dermatitis caused by the prolonged contact of human skin with body waste are disclosed. The methods of the present invention employ the topical application of a minimum inhibitory concentration of a pharmaceutically-acceptable lipase-inhibiting agent to the area in need of such treatment, or the area where prevention is desired. The lipase-inhibiting agent is preferably a water-soluble metallic salt, such as ZnCl2, and is preferably applied in combination with a barrier-like vehicle. The effective- ness of these methods is surprising in light of the present confu- sion and controversy surrounding the actual causes of diaper rash, and the heretofore unrecognized role of lipase as a factor in the cause of diaper rash and diaper dermatitis.

445839

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