Neurologically active pteridine analogues

Details Neurologically active pteridine analogues Neurologically active pteridine analogues

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 475/04 (2006.01) A61K 31/505 (2006.01) C07D 241/26 (2006.01) C07D 475/08 (2006.01)

Patent

CA 1288099

Abstract The use of compounds of the formula (I): Image or pharmaceutically acceptable salts or bio-precursors thereof; wherein R1 is hydrogen, C1-4 alkyl, C2-4 alkenyl, a group -BX(R5)n, or - BZBX(R5) wherein Z and X (when n=1) are the same or different and each is -O, -S(O)q or -NR6- wherein q is 0, 1 or 2 and R6 is hydrogen or C1-4 alkyl or, when n=O, X is halogen; R5 is hydrogen, C1-12 aralkyl or C1-10alkyl; B is C1-5 alkanyl; R2 is hydrogen, C1-4 alkyl, C2-4 alkenyl, or a group BOR7 wherein R7 is hydrogenor C1-6 alkyl; or R1 and R2 together with the carbon atoms in the pteridine ring structure to which they are attached form a C5-7 cycloalkyl ring; provided that at least one of R1, R2, R3, and R4 is hydrogen and that one of R1,R2, and R3, R4 represents gem di-substitution unless R1 represents CH2OR7 in which case R2, R3 and R4 can all be hydrogen, in the treatment of neurological disorder is disclosed. Pharmaceutical compositions containing compounds of the formula (1), novel compounds and processes for preparing the novel compounds are also disclosed. RSB/KMS/B375/19.08.83

437101

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