A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/101, 167/139
A61K 51/10 (2006.01) A61K 47/48 (2006.01) A61K 49/00 (2006.01)
Patent
CA 1340071
A polyspecific anti-leukocyte antibody conjugate for targeting foci of leukocyte accretion comprises an immunoreactive polyspecific composite of at least two different substantially monospecific antibodies or antibody fragments, conjugated to at least one imaging agent, wherein at least two of said antibodies or antibody fragments specifically bind to different leukocyte cell types. A method for targeting an imaging agent to an inflammatory or infectious lesion comprises injecting a mammal parenterally with an effective amount for targeting of the above anti-leukocyte imaging conjugate. A therapeutic anti-leukocyte conjugate for targeting foci of leukocyte accretion comprises at least one immunoreactive substantially monospecific antibody of antibody fragment which specifically binds to at least on leukocyte cell type, conjugated to a therapeutic antimicrobial agent, boron addend and/or radionuclide. A method of treatment of an infectious lesion comprises injecting a mammal parenterally with an effective amount for therapy of the above anti-leukocyte therapeutic conjugate.
606821
Goldenberg Milton David
Hansen Hans J.
Immunomedics Inc.
Smart & Biggar
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