6-bromocholesterol derivatives

Details 6-bromocholesterol derivatives 6-bromocholesterol derivatives

C - Chemistry, Metallurgy

07

J

260/60

C07J 9/00 (2006.01) A61K 51/04 (2006.01)

Patent

CA 1204434

TITLE OF THE INVENTION NOVEL 6-BROMOCHOLESTEROL DERIVATIVES ABSTRACT OF THE DISCLOSURE Novel 6-bromo derivatives of cholesterol have the formula Image - 2 - Such compounds are prepared from the known 6-iodocholesterol by treatment with cuprous bromide. These compounds, labelled with radioisotopes of Br-82 or Br-77, are localized in the adrenal, mammary and ovary tissue of female mammals and in the adrenal or prostate tissue of males when administered to such individuals. This provides a method for imaging adrenal, ovary or prostate tissue which is superior to use of the prior art 6-iodo-cholesterol.

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