Bicyclic aminoacid intermediates, process for their...

Details Bicyclic aminoacid intermediates, process for their... Bicyclic aminoacid intermediates, process for their...

C - Chemistry, Metallurgy

07

D

260/317

C07D 209/70 (2006.01) C07D 209/58 (2006.01) C07D 221/22 (2006.01) C07K 5/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1232280

The invention relates to new compounds of the formula III (see formula I) wherein the H atom on C-2 and C-6 are in the cis-configuration relative to one another, the group -CO2W on C-4 is orientated in the cis- or trans-position relative to the H atom on C-2 and the pyrrolidine ring is orientated in the exo- or endo-position relative to the bicyclic radical, and in which W denotes hydrogen or a radical which can be split off under acid, basic or hydrogenolytic conditions, and a process for the preparation. Compounds of the formula III are useful intermediates in the production of derivatives of tricyclicamino acids which in turn have hypotensive action and are powerful inhibitors of the angiotension-converting enzymes (ACE inhibitors).

515925

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