A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/162, 167/103
A61K 9/50 (2006.01) A61K 9/16 (2006.01) A61K 47/00 (2006.01) A61K 37/02 (1990.01) A61K 37/24 (1990.01)
Patent
CA 1333258
High molecular weight drugs such as peptides are not well absorbed across biological membranes such as the nasal mucosa. Absorption can be increased if the drug is given together with an absorption enhancing material. However, it has been found that such material can have an irritant effect on the membrane. The invention provides a drug delivery composition for transmucosal delivery comprising a plurality of microspheres and active drug associated with each microsphere, the drug being for systemic delivery and having a maximum molecular weight of 6000 and the composition being substantially free of an enhancer. The microspheres may be starch, gelatin, collagen or dextran. The composition has been found to increase the absorption of drugs, particularly peptides such as insulin, across mucosal membranes. The compositions are suitable for delivery across mucosal surfaces such as the nose, vagina or eye.
579773
Uren John Russell
West Pharmaceutical Services Drug Delivery & Clinical Research C
LandOfFree
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