Fluorinated amino-butyric acid and diaminobutane derivatives

Details Fluorinated amino-butyric acid and diaminobutane derivatives Fluorinated amino-butyric acid and diaminobutane derivatives

C - Chemistry, Metallurgy

07

D

260/506, 260/543

C07D 209/48 (2006.01) C07C 271/22 (2006.01)

Patent

CA 1181085

ABSTRACT OF THE DISCLOSURE Novel fluorinated aminobutyric acid and diamino-butane derivatives are inhibitors of gamma-aminobutyric acid transaminase and have the following general formula I:- Image Formula I wherein:- Y represents hydrogen or fluorine; Z represents -CH2NR1R2, where R1 and R2 are as defined below, or -COR3 where R3 is as defined below; Ra represents hydrogen or R4, where R4 is as defined below; R1 represents hydrogen, C1-C8 alkyl or phenyl-C1-C4 alkyl; R2 represents hydrogen, C1-C8 alkyl, phenyl- C1-C4 alkyl or, when Ra is hydrogen, R4, where R4 is as defined below; R3 represents hydroxy; or when Ra is hydrogen, C1-C8 alkoxy, -NR5R6, where R5 and R6 are as defined below, or an aminocarboxylic acid residue derived by removal of a hydrogen atom from the amino moiety of an L-aminocarboxylic acid; each R4 independently represents C2-C5 alkylcarbonyl, phenylcarbonyl, phenyl-(C1-C4 alkyl)carbonyl, or an aminocarboxylic acid residue derived by removal of an hydroxy group from the carboxy moiety of an L-aminocarboxylic acid; R5 and R6 independently represent hydrogen or C1-C4 alkyl; and p represents 1 or 2.

384351

Affiliated with

Also associated with

Rating

Fluorinated amino-butyric acid and diaminobutane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Fluorinated amino-butyric acid and diaminobutane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Fluorinated amino-butyric acid and diaminobutane derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1256550