C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
530/5.1, 167/103
C07K 5/10 (2006.01) C07K 5/103 (2006.01) C07K 5/107 (2006.01) C07K 5/117 (2006.01)
Patent
CA 1248699
ABSTRACT OF THE DISCLOSURE Novel peptides having the general formula (I): Image (I) wherein A denotes an amino acid residue which may optionally have protecting group; R1 denotes hydrogen atom, lower alkyl group, acyl group, alkoxycarbonyl group, or aralkyloxycarbonyl group which may optionally be substituted with halogen atom, alkoxy group, or nitro group; R2 denotes hydroxy group, alkoxy group, aryloxy group, aralkyloxy group, or amino group which may optionally be substituted with lower alkyl group; R3 denotes hydrogen atom, lower alkyl group, acyl group, or aralkyl group; R4 denotes hydrogen atom, tosyl group, trityl group, aralkyl group, or aralkyloxycarbonyl group which may optionally be substituted with halogen atom, alkoxy group, or nitro group; R5 denotes hydrogen atom, lower alkyl group, acyl group, tosyl group, alkoxycarbonyl group, or aralkyloxycarbonyl group which may optionally be substituted with halogen atom, alkoxy group, or nitro group; and pharmaceutically acceptable salts; a process for manufacturing them; pharmaceutical compositions containing them as active ingredient; and a method for treating ulcer and thrombus therewith.
414280
Borden Ladner Gervais Llp
Nippon Zoki Pharmaceutical Co. Ltd.
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