Cationic compounds useful for making radiodiagnostic agents

Details Cationic compounds useful for making radiodiagnostic agents Cationic compounds useful for making radiodiagnostic agents

C - Chemistry, Metallurgy

07

F

260/383, 167/48,

C07F 9/50 (2006.01) A61K 51/04 (2006.01) C07F 9/54 (2006.01) C07F 9/70 (2006.01)

Patent

CA 1207332

ABSTRACT OF THE DISCLOSURE A normally solid, hydrophilic compound capable of binding the Tc-99m to form a cationic complex is provided. The compound has a formula selected from: (A) Image or (B) Image wherein: R, R', R", R1, R2, R3, R4, R5 and R6 are each in- dependently selected from hydrogen; or substituted or un- substituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclic groups; and R plus Ri in formula (A) may be taken together to form a cyclic compound; A, A', A", A1, A2, A3, A4, A5 and A6 are indepen- dently neutral functional elements, each having a free electron pair available for accepting a proton to provide a charged ligand and having the capability of complexing with Tc-99m to form a cationic complex; Y1, Y2, Y3, Y4, Y5 and Y6 are each independently selected from hydrogen; or substituted or unsubstituted alkyl, alkylene, aryl, alkylaryl, arylalkyl, monocycloalkyl, polycycloalkyl, heterocyclic and carbocyclin groups; Z is an anion; i is an integer from 0 to 6; j, j' and j'' are each independently 0 or 1; k1, k2, k3, k4, k5 and k6 are each independently 0 or 1; n, n' and n'' are each independently the integer 1 or 2; n1, n2, n3, n4, n5, n6, are independently 0 or 1; and n7 and n8 are each an integer from 1 to 6; and n9 and n10 are each an integer from 1 to 3. These compounds are capable of reducing technetium to form stable cationic complexes. Radiolabelled such complexes are useful in connection with radiodiagnositic test of myocardial and/or hepatobiliary tissues.

406811

Affiliated with

Also associated with

Rating

Cationic compounds useful for making radiodiagnostic agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cationic compounds useful for making radiodiagnostic agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cationic compounds useful for making radiodiagnostic agents will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1258103