B - Operations – Transporting – 01 – D
Patent
B - Operations, Transporting
01
D
128/81
B01D 36/02 (2006.01) A61M 1/36 (2006.01) B01D 67/00 (2006.01) B01J 20/32 (2006.01)
Patent
CA 1326418
Abstract of the Disclosure Heparin in an extracorporeal blood flow circuit is removed from the blood flow with the use of a filter which contains immobilized protamine on a blood-compatible support. In medical procedures where blood is processed in an extracorporeal device, such as an artificial kidney, or a heart-lung machine, the blood is heparinized to prevent clotting thereof in the channels of the extracorporeal device, and the formation of thrombi. In accordance with the invention, the processed, heparinized blood is conducted to a filter arrangement wherein protamine is held immobilized on a support formed of a blood-compatible material. Such an arrangement actually removes heparin from the blood rather than merely negates the anticoagulation effects of the heparin, as is the case in conventional protamine infusion therapy. In the present invention, the extracorporeal blood which is returned to the patient is substantially free of both heparin and protamine. Various chemical mechanisms are presented for activating a polymeric support material so as to bond covalently with the protamine.
580984
Smart & Biggar
University Of Michigan (the)
LandOfFree
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