Purified igm

Details Purified igm Purified igm

A - Human Necessities

61

K

167/139

A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 16/12 (2006.01) C12N 5/12 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341474

An essentially pure and stabilized antibody preparation comprising IgM antibodies having a purity greater than about 98% by weight and a nucleic acid content of less than about 200 pg per mg IgM. In one embodiment IgM antibodies from a monoclonal source are subjected to ion exchange and size exclusion chromatography at an alkaline pH to yield a purified IgM having a nucleic acid content of less than 10 pg/mg IgM, preferably less than about 4 pg/mg IgM. A highly purified and stabilized preparation of anti Pseudomonas aeruginosa antibodies is disclosed.

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