Stabilized, dilute aqueous preparation of 1.alpha., 25-...

Details Stabilized, dilute aqueous preparation of 1.alpha., 25-... Stabilized, dilute aqueous preparation of 1.alpha., 25-...

A - Human Necessities

61

K

167/283

A61K 31/59 (2006.01) A61K 47/00 (2006.01)

Patent

CA 1174605

Canada - #3835 A B S T R A C T 1.alpha.,25-Dihydroxycholecalciferol, also known as 1.alpha.,25-dihydroxyvitamin D3, calcitriol or 1.alpha.,25(OH)2D3, occurs naturally in man as the active form of cholecalciferol or vitamin D3. The natural supply of vitamin D3 depends on the conversion of 7-dehydrocholesterol to vitamin D3 in the skin by ultraviolet light. Vitamin D3 is then converted to calcitriol in a two-step process in the liver and kidney before it acts on its target tissue. 1.alpha.,25-Dihydroxycholecalciferol is represented by the formula: Image The compound has a molecular weight of 416.647, a molecular formula of C27H44O3, is soluble in organic solvents and practically insoluble in water.

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