Substituted hexahydropyrrolo¬1,2-a|quinoline,...

Details Substituted hexahydropyrrolo¬1,2-a|quinoline,... Substituted hexahydropyrrolo¬1,2-a|quinoline,...

C - Chemistry, Metallurgy

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C07C 69/76 (2006.01) C07C 33/20 (2006.01) C07C 205/33 (2006.01) C07D 207/08 (2006.01) C07D 211/34 (2006.01) C07D 307/10 (2006.01) C07D 307/16 (2006.01) C07D 309/04 (2006.01) C07D 311/78 (2006.01) C07D 455/02 (2006.01) C07D 455/04 (2006.01) C07D 471/04 (2006.01)

Patent

CA 1254567

SUBSTITUTED HEXAHYDROPYRROLO[1,2-a]- QUINOLINE, HEXAHYDRO-1H-PYRIDO[1,2-a]- QUINOLINE, HEXAHYDROBENZO[e]INDENE AND OCTAHYDROPHENANTHRENE CNS AGENTS Abstract Tricyclic benzo fused compounds of the formula Image ---(I) and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2R4, COR5, C(OR7) R5R6, CN, CONR9R10, CH2NR9R10, CH2NHCOR11, CH2NHSO2R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryl- oxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.

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