Substituted imidazopyrimidines-pyrazines, and - triazines

Details Substituted imidazopyrimidines-pyrazines, and - triazines Substituted imidazopyrimidines-pyrazines, and - triazines

C - Chemistry, Metallurgy

07

D

167/211, 260/242

C07D 487/04 (2006.01) A61K 31/495 (2006.01) A61K 31/53 (2006.01) C07C 45/46 (2006.01) C07C 45/54 (2006.01) C07C 45/67 (2006.01) C07C 45/71 (2006.01) C07C 49/84 (2006.01)

Patent

CA 1262460

Abstract Compounds having the formula (I) Image I and their pharmaceutically acceptable salts, wherein one or two of A1, A2, A3, and A4 is N, and the remain- ing A1, A2, A3, and A4 are CH, provided that if A4 is N, then one of A1, A2, and A3 is also N, and provided that one of A1,.A2, and A3 may be CX where X is halo; and each of R1, R2, and R3 is independently hydrogen, C1-C4 alkyl, C1-C4 alkoxy, allyloxy, benzyloxy, (C1-C4 alkyl)thio, (C1-C4 alkyl)sulfinyl, (C1-C4 alkyl)sul- fonyl, hydroxy, halo, cyano, nitro, amino, mono- or di-(C1-C4 alkyl)amino, trifluoromethyl, or Z-Q-substi- tuted C1-C4 alkoxy, wherein Q is oxygen, sulfur, sul- finyl, sulfonyl, or a bond, and Z is C1-C4 alkyl, phenyl or phenyl substituted with halo, C1-C4 alkyl, C1-C4 alkoxy, hydroxy, nitro, amino, C1-C4 alkylthio, C1-C4 alkylsulfinyl, or C1-C4 alkylsulfonyl are inotropic agents or intermediates thereto.

443849

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