Peptides having bradykinin antagonist action

Details Peptides having bradykinin antagonist action Peptides having bradykinin antagonist action

C - Chemistry, Metallurgy

07

K

530/7.06, 167/10

C07K 7/06 (2006.01) A61K 38/08 (2006.01) C07K 7/18 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340667

Peptides having bradykinin antagonist action Peptides of the formula I A-B-C-E-F-K-(D)-Tic-G-M-F'-I (I) in which A stands for hydrogen, alkyl, alkanoyl, alkoxycarbonyl, alkylsulfonyl, cycloalkyl, aryl, arylsulfonyl, heteroaryl or an amino acid which may optionally be substituted, B is a basic amino acid, C denotes a dipeptide or tripeptide, E stands for the radical of an aromatic amino acid, F independently of one another denotes an amino acid which is optionally substituted in the side chain or a direct bond, G is an amino acid, F' is as defined for F, -NH-(CH2)2-8 or may optionally denote a direct bond, I is -OH, -NH2 or -NHC2H5 and K denotes a radical -NH-(CH2)1-4,-CO- or stands for a direct bond, have bradykinin antagonist action. Their therapeutic utility includes all pathological states which are mediated, caused or supported by bradykinin and bradykinin-related peptides. The peptides of the formula I are prepared by known methods of peptide synthesis.

607853

Affiliated with

Also associated with

Rating

Peptides having bradykinin antagonist action does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Peptides having bradykinin antagonist action, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Peptides having bradykinin antagonist action will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1263131