Modified factor vii/viia

Details Modified factor vii/viia Modified factor vii/viia

C - Chemistry, Metallurgy

12

N

195/39.1, 195/1.

C12N 15/57 (2006.01) C12N 9/64 (2006.01)

Patent

CA 1339815

Modified factor VII/VIIa stabilized against proteolytic cleavage at certain positions in the molecule is provided. The stabilization is obtained by replacement of one or more proteolytically sensible peptide bonds in native human factor VII/VIIa with a proteolytically more stable peptide bond. Preferably certain Arg and/or Lys residues are replaced with other amino acids.

570535

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