Anthelmintically active...

C - Chemistry – Metallurgy – 07 – D

Patent

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260/314.3

C07D 235/32 (2006.01)

Patent

CA 1069909

ABSTRACT OF THE DISCLOSURE This invention is directed to a process for the preparation of a 2-alkoxycarbonylamino-5(6)-phenylsulfonyloxy- benzimidazole of the formula (1) Image (1) wherein R1 represents alkyl of 1 to 4 carbon atoms, R2 and R3, independently of one another, each represents hydrogen, hydroxy, alkoxy of 1 to 4 carbon atoms, halogen, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxycarbonyl of 1 to 4 carbon atoms in the alkoxy radical, or cyano by the reaction of a 2-alkoxycarbonyl- amino-5(6)hydroxybenzimidazole with a benzene-sulfonic acid halide in the presence of a base. The products are valuable chemo- therapeutic agents suitable for combatting diseases caused by parasites in humans and animals such as helminths and liver flukes.

261425

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