Human monoclonal antibody to lymphadenopathy associated virus

Details Human monoclonal antibody to lymphadenopathy associated virus Human monoclonal antibody to lymphadenopathy associated virus

C - Chemistry, Metallurgy

12

N

167/140, 167/37,

C12N 5/28 (2006.01) A61K 39/42 (2006.01) C07K 1/22 (2006.01) C07K 16/10 (2006.01) C12N 5/10 (2006.01) C12N 5/24 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1339830

Human monoclonal antibodies capable of specifically reacting with an antigenic determinant of LAV/HTLV-III and cell lines producing those monoclonal antibodies are disclosed. The human monoclonal antibodies may be utilized in a method for determining the presence of LAV/HTLV-III in biological samples, or in a method for separating specific antigenic determinants of LAV/HTLV-III from a mixture. Pharmaceutical compositions containing such a human monoclonal antibody, and a method for significantly reducing the infectivity of LAV/HTLV-III in animals using the composition are also disclosed.

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