Cephalosporin antibiotics

Details Cephalosporin antibiotics Cephalosporin antibiotics

C - Chemistry, Metallurgy

07

D

167/188, 260/104

C07D 501/34 (2006.01) C07C 59/315 (2006.01) C07C 69/708 (2006.01) C07D 498/04 (2006.01)

Patent

CA 1265512

ABSTRACT Cephalosporin antibiotics There are described compounds of formula (I) Image (I) wherein R, R1 and R2 which may be the same or different, each represents a hydrogen atom or a C1-4 alkyl group and R3 represents a C1-4 alkyl group with the proviso that, when both R1 and R2 represent hydrogen atoms, R3 represents other than a methyl group. These cefuroxime esters are valuable as providing orally adminis- trable forms of the antibiotic cefuroxime. Methods of preparing cefuroxime esters, pharmaceutical compositions containing the esters and methods for their use in medicine are also described. Novel intermediates for use in the preparation of the cefuroxime esters are also described.

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