Process for the manufacture of novel benzophenones

Details Process for the manufacture of novel benzophenones Process for the manufacture of novel benzophenones

C - Chemistry, Metallurgy

07

C

167/246, 260/489

C07C 61/39 (2006.01) C07C 69/757 (2006.01) C07C 103/22 (1985.01)

Patent

CA 1242448

Process for the manufacture of novel benzophenones Abstract Substituted benzophenones of the formula Image (I) in which Ph represents unsubstituted or substituted phenyl and R represents free, esterified or amidated carboxy, have anti-inflammatory and/or analgesic properties and can be used as active ingredients in medicaments. They are manufactured, for example, as follows: a compound or a mixture of compounds of the formula Image (II) in which X1 and X2 together represent a group of the formula -C(=O)-O that is bonded via the carbonyl group to the radical Ph and X3 represents hydrogen, or one of the radicals X1 and X3 represents a group of the formula -C(=O)-Z, the other represents hydrogen and X2 represents a group R'O- in which R' represents hydrogen or a hydroxy-protecting group, is subjected to acid treatment and the primary product is decomposed solvolytically.

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