Preparation of 2-t-butyl-5-hydroxypyrimidine by hydrolysis...

Details Preparation of 2-t-butyl-5-hydroxypyrimidine by hydrolysis... Preparation of 2-t-butyl-5-hydroxypyrimidine by hydrolysis...

C - Chemistry, Metallurgy

07

D

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C07D 239/34 (2006.01) C07D 239/30 (2006.01)

Patent

CA 1250578

ABSTRACT OF THE DISCLOSURE The hydrolysis of 2-t-butyl-5-halopyrimidines is carried out in the presence of an alkali metal meth- oxide and a catalytic amount of an N-oxide, a disulfide or elemental sulfur to prepare 2-t-butyl-5-hydroxypyri- midine in good yields and purity. The 2-t-butyl-5- chloropyrimidine which may be used can be made by the direct chlorination of 2-t-butylpyrimidine with elemental chlorine in an acetic or propionic acid solution at temperatures of 40° to 90°C in the presence of a buffer.

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