Prostaglandins

Details Prostaglandins Prostaglandins

C - Chemistry, Metallurgy

07

D

167/179, 260/235

C07D 491/08 (2006.01) A61K 31/557 (2006.01) C07C 43/315 (2006.01) C07C 45/44 (2006.01) C07C 59/62 (2006.01) C07C 405/00 (2006.01) C07D 493/08 (2006.01)

Patent

CA 1243312

ABSTRACT PROSTAGLANDINS Novel compounds have a formula (I) Image (I) wherein Image represents a bicyclo [2,2,1] hept-2Z-ene, bicyclo [2,2,1] heptane, 7-oxa-bicyclo [2,2,1] hept-2Z-ene, 7-oxa-bicyclo [2,2,1] heptane, bicyclo [2,2,2] oct-2Z-ene or bicyclo [2,2,2] octane substituted at the 5-position by the group R1 and at the 6-position by the group ANR2R, a 6,6-dimethyl-bicyclo [3,1,1] heptane substituted at the 2-position by the group R1 and at the 3-position by the group ANR2R or at the 2-position by the group ANR2R and at the 3-position by the group R1, a cyclohex-1-ene or cyclohexane substituted at the 4-position by the group R1 and at the 5-position by the group ANR2R or a 1-hydroxycyclopentane substituted at the 2-position by the group R1 and at the 2-position by the group ANR2R, R1 is a 6-carboxyhex- 2-enyl group or a modification thereof as defined herein; A is an unbranched or branched aliphatic hydrocarbon group with a chain length between the points of attachment to the divalent cyclic group and to the group NR2R of 1 to 5 carbon atoms or such a group substituted by an aromatic group; R2 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups; and R is a group -CO.NR3R4, -CS.NR3R4, -CNH.NR3R4, -CO.R4 or -CS.R4 in which R3 is hydrogen, an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted by an aromatic group or groups, and R4 is an aliphatic hydrocarbon group, an aromatic group or an aliphatic hydrocarbon group substituted directly by an aromatic group or groups and/or through an oxygen or sulphur atom either by an aromatic group or by an aliphatic hydrocarbon group substituted directly by an aromatic group or groups. The compounds are of value for use in pharmaceutical compositions particularly in the context of the inhibition of thromboxane activity.

418379

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