Monoclonal antibodies specific for human hematopoietic cell...

Details Monoclonal antibodies specific for human hematopoietic cell... Monoclonal antibodies specific for human hematopoietic cell...

A - Human Necessities

61

K

167/37, 195/1.11

A61K 39/395 (2006.01) C07K 16/28 (2006.01) C12N 5/00 (2006.01)

Patent

CA 1177764

ABSTRACT Monoclonal antibodies are produced for a family of glycoproteins which are selectively expressed on the surface of nucleated human hemotopoietic cells but which are absent from other normal human cells. Mice are inoculated with human hematopoietic cells or fragments thereof, and spleen cells obtained from the mice are fused with mice myeloma cells to produce hybridomas. The hybridomas are cultured as clones, and antibodies obtained from the individual clones are tested for their specificity for hematopoietic cells. Clones which produce antibodies specific for surface glycoproteins of nucleated human hematopoietic cells are selected for further culturing to produce the antibody, and the antibody is obtained from the culture growth medium or from ascitic fluid of mice bearing the hybridoma tumor.

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