Antibacterial penem derivatives

Details Antibacterial penem derivatives Antibacterial penem derivatives

C - Chemistry, Metallurgy

07

D

260/111

C07D 499/00 (2006.01) C07D 205/08 (2006.01) C07D 205/09 (2006.01) C07D 333/38 (2006.01) C07D 499/88 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1225392

- 1 - ANTIBACTERIAL PENEM DERIVATIVES Abstract: Penem derivative of the formula I Image I in which R is hydrogen or a carboxyl esterifying group, R1 is phenyl, naphthyl, thienyl, pyridyl, quinolyl or isoquinolyl being unsubstituted or substituted by one, two or three of the same or different substituents selected from halogen, hydroxy, amino, nitro, cyano, azido, alkyl, alkoxy, alkanesulfenyl, alkanesulfinyl, alkanesulfonyl, alkanoyl, alkoxycarbonyl, alkanoyloxy, carbamoyl, ureido, carbamoyl- oxy, alkanoylamino, aminosulfamoyl, sulfamoyl, guanidino, trifluormethyl, trifluormethane- sulfenyl, trifluormethanesulfinyl, trifluor- methanesulfonoyl and formyl, which may be substituted by one, two or three lower alkyl groups being the same or different. R2 represents a hydrogen atom ir a optionally protected hydroxyl group, or a salt thereof, process for the production thereof and antibacterial pharma- ceutical preparations comprising them.

406827

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