Furo-(3,4-c)-pyridine derivatives preparation thereof and...

Details Furo-(3,4-c)-pyridine derivatives preparation thereof and... Furo-(3,4-c)-pyridine derivatives preparation thereof and...

C - Chemistry, Metallurgy

07

D

167/231, 260/276

C07D 491/048 (2006.01) A61K 31/44 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1257269

A B S T R A C T This invention relates to 1,3-dihydro-6-methyl-7- hydroxy-furo-(3,4-c)-pyridine derivatives of the general formula I Image I wherein each of A1 and A2 independently represents various hydrocarbon groups and therapeutically acceptable addition salts thereof ; to a process for the preparation of the same comprising oxidizing the secondary alcohol .alpha.4, 3-o- isopropylidene-1-methyl-5-(l-hydroxy-l-A1)-methyl pyridine by any usual technique, reacting the resultant ketone with a compound of the general formula XA2 wherein X stands for Br or I in the presence of magnesium in diethyl ether at the boil and treating the resultant tertiary alcohol with an acidic agent to provoke breaking of the isopropylidene ring and 3,4-cyclisation ; and to pharmaceutical compositions containing these derivatives. The compounds are used in diuresis in the lowering of blood pressure, in kidney protection and also as anti-histaminic agents.

451348

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