A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
167/127
A61K 31/555 (2006.01) C07D 495/14 (2006.01)
Patent
CA 1222949
Abstract There are described the novel compound bis-(trimetha- phan)-nitroprusside (I), and solvates, especially hydrates or alcoholates thereof, as well as a process for the manu- facture thereof from an alkali nitroprusside and a soluble trimethaphan salt, especially sodium nitroprusside and trimethaphan camsylate, in solution, especially in water. Furthermore, there are described pharmaceutical com- positions which contain the novel active substance (I) in solid form, in form of concentrated solutions or in form of diluted solutions suitable for infusion purposes. In particular there are described compositions which contain (I) in concentrated solution in at least 40% ethanol or in solid form as well as compositions which contain, in addition to (I), a soluble, physiologically acceptable thiosulphate, in particular sodium thiosulphate. The preparation of infusion solutions from the con- centrated solutions or mixtures, the preparation of an especially well soluble micronized mixture of (I) and thiosulphate and the use of the concentrate for the pre- paration of infusion solutions are also described. The compound (I) and its solvates and the pharmaceu- tical compositions containing (I) are suitable for thera- peutic use, particularly in the lowering of blood pressure, in the achievement of peripheral vasodilation, in the elimi- nation of arterial spasms and/or in the reduction of myo- cardial oxygen consumption and of the work load of the heart after heart attack.
419966
Cierpka Henning
Cierpka Henning
Gowling Lafleur Henderson Llp
LandOfFree
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