Retinoid acylates of sugars and amino sugars

Details Retinoid acylates of sugars and amino sugars Retinoid acylates of sugars and amino sugars

C - Chemistry, Metallurgy

07

H

260/227, 167/243

C07H 5/06 (2006.01) C07H 13/04 (2006.01)

Patent

CA 1234107

Abstract The novel retinoids of the general formula Image I wherein R represents a residue of a sugar attached ester-wise or a residue of an amino-sugar attached amide-wise or of derivatives of such sugars and n is 1 or 2. can be used as medicaments, e.g. for the treatment of neo- plasms, acne and psoriasis. These compounds are abtained by reacting a sugar or an aminosugar or a derivative thereof with a reactive derivative of 9-(4-methoxy-2,3,6- trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid, optionally followed by the modification of reactive groups present in the reaction product.

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