Substance, composition of matter and method of using same

Details Substance, composition of matter and method of using same Substance, composition of matter and method of using same

C - Chemistry, Metallurgy

07

D

167/227, 260/275

C07D 491/056 (2006.01) A61K 31/47 (2006.01) C07D 491/04 (2006.01)

Patent

CA 1297108

ABSTRACT OF THE DISCLOSURE A new antineoplastic substance denominated "pancratistatin", Methods of isolating natural and synthetic pancratistatin and 7-deoxynarciclasine and the pharmaceutically acceptable derivatives thereof to make a pharmaceutical preparation therefrom and methods for treating a host afflicted with a neoplasm with said preparations. Substances suitable for use in the present invention have a structure selected from the group consisting of: Image Image and wherein R is H, CH3 or COX; and Rl, R2, R3 and R4, independently, are H or COX, wherein X is Cl-20alkyl, C2-20alkenyl, C9-12aryl, or a heterocyclic selected from thiazoyl, thiophenoyl, pyridoyl, pyrimidoyl and furoyl.

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