Process for the manufacture of novel amidines

Details Process for the manufacture of novel amidines Process for the manufacture of novel amidines

C - Chemistry, Metallurgy

07

D

260/242.01

C07D 487/04 (2006.01) C07D 209/18 (2006.01)

Patent

CA 1216848

Process for the manufacture of novel amidines Abstract of the Disclosure Novel amidines, especially M,N'-bridged carboxylic acid amidines of the general formula Image (I), in which Rl represents phenyl optionally substituted in the p-position by lower alkylthio having up to and including 4 carbon atoms, by lower alkanesulphinyl having up to and including 4 carbon atoms, by lower alkoxy having up to and including 4 carbon atoms or by halogen having an atomic number of up to and including 35, thienyl,or pyridyl optionally substituted by lower alkyl having up to and including 4 carbon atoms, R2 represents carboxymethyl or, secondly, lower alkoxy- carbonylmethyl having up to and including 5 carbon atoms, Ph represents 1,2-phenylene optionally substituted in the p-position to the nitrogen atom by lower alkoxy having up to and including 4 carbon atoms or by halogen having an atomic number of up to and including 35 and alk represents vinylene, and salts thereof, have, inter alia, anti-inflammatory activity and can be used in pharmaceutical preparations as an active ingredient in medicaments. They are manufactured according to methods known per se.

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